H1N1 & Tamiflu resistance
Posted on October 15, 2009
Filed Under H1N1 Treatment & Drugs | Leave a Comment
Acquire the virus while the significance of what?
Li Xiaomeng: Mainland’s first strain of the virus have been successfully separated, and the significance of this virus was where?
Shuyue Long: I think this virus should have access to two aspects of the significance of one of our China, because we had no viruses, no pathology, but unfortunately we have imported cases, and we wanted to know The virus is not and abroad is consistent, and they have no difference, so we need to get this virus. To get this virus, we are after a day of work on the genetic sequence of this virus was determined, by comparison, this virus and the United States, Canada, Mexico and other countries are basically the same virus isolated can be considered imported cases this is indeed a After returning from the United States, caused by the same virus, and this is the first significance. The second meaning, I think this virus isolation, you can for our future scientists, the establishment of detection methods, improvements, vaccine research, etiology related research materials.
How soon vaccine production?
Li Xiaomeng: Just to get an effective strain, the vaccine can be produced three or four months out?
Shu Yuelong: vaccine production, vaccine strains and simple isolated from a patient virus is still a difference, because the vaccine strains to go through a very complex process of cultivation in order to become vaccine factories used to produce the seed strain. Now the seeds of plants mainly in the United States and some other countries, CDC laboratory cultivation. Since April, when the United States had this virus, so they isolated the virus has been cultivated in the process of the U.S. CDC announced that probably by the end of May this year, when the vaccine for all manufacturers offer this vaccine seed strains. Including China, including vaccine manufacturers, will soon get the seed strain, and began vaccine production.
Why should constantly isolated viruses?
Li Xiaomeng: I know, Shandong, and Beijing, a sample of diagnosed patients have gradually been sent for virus isolation, why keep doing this work?
Shu Yuelong: We fear that the virus will change, how do we know if the virus changes? Attempt by a continuous separation of viruses, continuous determination of its sequence, it may find that the virus will change. But we can not guarantee that this virus to China, will not mutate, so we need to keep to isolate the virus, to detect the virus sequence to find that it can mutate place.
What changes might be the virus?
Li Xiaomeng: What are the variations of this virus possibility?
Shu Yuelong: Simply put, there are two possibilities exist in theory, one that, if this virus and the development of our other re-distribution of influenza viruses, and then produce a new virus, which is a possible variant approach. Another method is a variant of its own continued to accumulate mutations, because the influenza virus gene mutation is a constant law of nature, so the virus could continue their popularity in the crowd, and then continuously changed, so that the virus has become and now not the same, it is the virus mutates to two possibilities. Now we still do not know which direction it wants to change, or change how well the world’s scientists also think so, so each place should the virus be monitored. Monitoring means is just what I have said to separate virus, determination of the virus sequence analysis of its biological features.
Case development to intervention?
Li Xiaomeng: from imported to a non-imported cases in the development process, the human factor can go to intervention?
Shu Yuelong: human factors can intervene to interfere with what? It is the delay time, the case of Japan made it clear that it began only four cases were all imported cases, over a period of time, there is such a non-imported cases, not to say that these four cases of non-imported cases occurred, immediately, there were the so-called second-and third-generation cases, indicating that they have taken measures have slowed the process.
Why reduce the isolation and observation of the area?
Li Xiaomeng: just started to come from the affected areas of aircraft and found that patients with suspected or confirmed patients, the entire aircraft, personnel must be investigation, should be under medical observation, and now has developed into the first three rows, after three rows, reduce isolation the range of observation, why would such a development change?
Shu Yuelong: The close contact with those who judge, or the conditions of close contact with the judge who is determined by different studies of different stages of the epidemic outbreak in different situations, or to make them. From the beginning to the present, I would like to reflect a problem is that we understand it more and more, perhaps in the future our understanding of this infectious disease to learn more about the circumstances, may be the treatment of close contacts , isolation or other measures there will be other changes, my personal understanding is that, through the development of the epidemic, people understand it more and more.
Li Xiaomeng: My three imported cases were at the airport, successfully passed the test temperature, is not it shows temperature detect the presence of loopholes?
Shu Yuelong: It now appears that the body temperature test holes do exist, we should take additional measures. Such as inspection and quarantine departments have asked the immigrants to tell this period, travel plans and contact details, there are symptoms immediately after the report, these are right, if not found at the scene, followed by a number of remedial measures.
Virus resistant to Tamiflu have been?
Li Xiaomeng: Now we have an issue of great concern, primarily for the treatment of influenza A H1N1 influenza antiviral drugs Tamiflu There was an allegation of influenza virus has become resistant to it, and if so, prevention is even more difficult to 1:00 it?
Shu Yuelong: Currently Influenza A H1N1 influenza, it is still sensitive to the Tamiflu, by this time we have just measured the strains of the virus analysis also shows that this virus is still sensitive to Tamiflu, the drug class, and it has such a King Kong Amantadine, rimantadine class drug resistance, but this type of drug Tamiflu is still sensitive.
You just say this, there may be a bit confused, because before the advent of influenza A H1N1 influenza, in Europe and the United States, some developed countries, particularly in Europe, is already popular in the crowd inside the H1N1, which we call seasonal influenza H1N1 , its resistance to Tamiflu is very high class, and even reached 100 percent, because all call H1N1, as I understand there may be some misunderstanding here.
Li Xiaomeng: that is now the Influenza A H1N1 influenza, Tamiflu can still treat it?
Shuyue Long: Yes.
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